Design of oligothiophene-based tetrazoles for laser-triggered photoclick chemistry in living cells?

Chemical Communications Pub Date: 2013-09-03 DOI: 10.1039/C3CC45752D

Abstract

A 405 nm light-activatable terthiophene-based tetrazole was designed that reacts with a fumarate dipolarophile with the second-order rate constant k2 exceeding 103 M?1 s?1. The utility of this laser-activatable tetrazole in imaging microtubules in a spatiotemporally controlled manner in live cells was demonstrated.

Graphical abstract: Design of oligothiophene-based tetrazoles for laser-triggered photoclick chemistry in living cells
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