Copper-catalyzed versatile C(sp3)–H arylation: synthetic scope and regioselectivity investigations?
Organic Chemistry Frontiers Pub Date: 2019-03-29 DOI: 10.1039/C9QO00175A
Abstract
The copper-catalyzed versatile C(sp2)–C(sp3) bond formation with N-heteroaromatics and hydrogen donors was developed. Various alkanes and ethers reacted with quinolines, isoquinolins, pyridines, benzooxazole and benzothiazole to give the corresponding C(sp2)–H alkylation products via cross-dehydrogenative coupling. On the other hand, we achieved the high regioselective C(sp2)–halogen alkylation of (hetero)aryl chlorides and (hetero)aryl bromides with ethers via elimination of the halogen radical. The reaction mechanism was investigated with control experiments.
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Journal Name：Organic Chemistry Frontiers
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CAS no.: 89640-58-4
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