Copper-catalyzed acylation of pyrazolones with aldehydes to afford 4-acylpyrazolones?
Organic & Biomolecular Chemistry Pub Date: 2019-07-27 DOI: 10.1039/C9OB01486A
Abstract
Copper-catalyzed direct acylation of the alkenyl C–H bond in 1,2-dihydro-3H-pyrazol-3-ones has been developed, affording a series of 4-acylpyrazolones in moderate to good yields. Notably, this protocol involves readily accessible substrates and reagents, which have good functional group tolerance leading to pyrazolone derivatives under mild reaction conditions.
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Journal Name：Organic & Biomolecular Chemistry
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CAS no.: 89640-58-4
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