X-Ray diffraction analyses of the natural isoquinoline alkaloids Berberine and Sanguinarine complexed with double helix DNA d(CGTACG)?

Chemical Communications Pub Date: 2011-03-22 DOI: 10.1039/C1CC10971E

Abstract

The first crystal structures of Berberine and Sanguinarine intercalated with a d(CGTACG)2 DNA sequence were obtained by X-ray diffraction analysis at 2.3 ? resolution. Both drugs join the end of two “two-molecules” DNA units, stacked in a non-classic intercalation site formed by six bases. Sanguinarine interacts with d(CGTACG)2 DNA in its iminium form.

Graphical abstract: X-Ray diffraction analyses of the natural isoquinoline alkaloids Berberine and Sanguinarine complexed with double helix DNA d(CGTACG)
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