Visible light-promoted ring-opening functionalization of unstrained cycloalkanols via inert C–C bond scission??
Chemical Science Pub Date: 2018-06-11 DOI: 10.1039/C8SC01763H
Abstract
Described herein is a novel, useful, visible light-promoted ring-opening functionalization of unstrained cycloalkanols. Upon scission of an inert cyclic C–C σ-bond, a set of medium- and large-sized rings are readily brominated under mild reaction conditions to afford the corresponding distal bromo-substituted alkyl ketones that are hard to synthesize otherwise. The products are versatile building blocks, which are easily converted to other valuable molecules in one-step operation. This protocol is also applicable to the unprecedented ring-opening cyanation and alkynylation of unstrained cycloalkanols.
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Journal Name：Chemical Science
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CAS no.: 89640-58-4
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