Unexpectedly rigid short peptide foldamers in which NH–π and CH–π interactions are preserved in solution?

Chemical Communications Pub Date: 2021-07-19 DOI: 10.1039/D1CC02998C

Abstract

NH–π and CH–π interactions, due to their weak character, are not easily identified in solution. We report a group of isolable short peptides with stable folds, in which NH–π and CH–π main chain–side chain interactions can be detected in solution by means of NMR and ATR-IR spectroscopy.

Graphical abstract: Unexpectedly rigid short peptide foldamers in which NH–π and CH–π interactions are preserved in solution
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