Construction of the tetrahydroquinoline spiro skeleton via cascade [1,5]-hydride transfer-involved C(sp3)–H functionalization “on water”?
Green Chemistry Pub Date: 2017-10-24 DOI: 10.1039/C7GC02353G
Abstract
The pharmaceutically important tetrahydroquinoline spiro compounds were efficiently constructed via cascade SNAr/Knoevenagel condensation/[1,5]-hydride transfer/cyclization on water, featuring high atom-economy and step-economy. This water-based redox-neutral C(sp3)–H functionalization rendered a 4-step cascade reaction successful without resorting to any catalysts.
![Graphical abstract: Construction of the tetrahydroquinoline spiro skeleton via cascade [1,5]-hydride transfer-involved C(sp3)–H functionalization “on water”](http://scimg.chem960.com/usr/1/C7GC02353G.jpg)
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Journal Name：Green Chemistry
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CAS no.: 89640-58-4
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