ZnCl2-promoted domino reaction of 2-hydroxybenzonitriles with ketones for synthesis of 1,3-benzoxazin-4-ones?
RSC Advances Pub Date: 2021-09-06 DOI: 10.1039/D1RA04194K
Abstract
A ZnCl2-promoted synthesis of 1,3-benzoxazin-4-one from 2-hydroxybenzonitriles and ketones was developed. This method displays facile access to a diverse range of substituted 1,3-benzoxazin-4-ones in good yields. This synthetic protocol has advantages: (i) easy availability of starting material; (ii) strong corrosive acid-free condition; (iii) high yield.
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Journal Name：RSC Advances
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CAS no.: 89640-58-4
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