Transition-metal-free decarboxylation of dimethyl malonate: an efficient construction of α-amino acid esters using TBAI/TBHP?
Organic & Biomolecular Chemistry Pub Date: 2015-02-11 DOI: 10.1039/C5OB00109A
Abstract
A transition-metal-free decarboxylation coupling process for the preparation of α-amino acid esters, which succeeded in merging hydrolysis/decarboxylation/nucleophilic substitution, is well described. This strategy uses commercially available inexpensive starting materials, catalysts and oxidants and has a wide substrate scope and operational simplicity.
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Journal Name：Organic & Biomolecular Chemistry
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CAS no.: 89640-58-4
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