Transition metal-free α-methylation of 1,8-naphthyridine derivatives using DMSO as methylation reagent?
Organic & Biomolecular Chemistry Pub Date: 2019-07-25 DOI: 10.1039/C9OB01490J
Abstract
A practical approach to the direct α-methylation of 1,8-naphthyridines under mild reaction conditions has been developed using simple and readily available DMSO as a convenient and environmentally friendly carbon source. This method is transition metal-free and highly chemoselective, shows good functional group tolerance, and uses DMSO as a methyl source, providing efficient and rapid access to an important compound class, 2-methyl-1,8-naphthyridines.
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Journal Name：Organic & Biomolecular Chemistry
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CAS no.: 89640-58-4
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