Transition metal-free oxidative ortho-acylation of phenols with N-heteroarylmethanes via double C–H activation?
Catalysis Science & Technology Pub Date: 2016-06-27 DOI: 10.1039/C6CY01301E
Abstract
The direct oxidative acylation of phenols with N-heteroarylmethanes via sp3C–H and sp2C–H double activation was achieved under transition metal-free reaction conditions. This transformation proceeds in a facile I2/DMSO/O2 system regio-selectively to produce valuable (2-hydroxyphenyl)arylmethanones from easily available starting materials in moderate to good yields. A plausible mechanism was proposed.
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Journal Name：Catalysis Science & Technology
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