Visible-light induced decarboxylative alkylation of quinoxalin-2(1H)-ones at the C3-position?

Organic & Biomolecular Chemistry Pub Date: 2019-06-15 DOI: 10.1039/C9OB01169B

Abstract

A simple and efficient method for the visible light induced direct carbon alkylation of quinoxalin-2(1H)-ones at the C3 position is described. This protocol employs cheap and readily available phenyliodine(III) dicarboxylates as the alkylation reagents to conduct decarboxylative radical coupling reaction with quinoxalin-2(1H)-ones. The process exhibits excellent compatibility to functional groups and provides a convenient and selective access to various 3-alkylquinoxalin-2(1H)-ones in good yields.

Graphical abstract: Visible-light induced decarboxylative alkylation of quinoxalin-2(1H)-ones at the C3-position
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