Zn(OTf)2-catalyzed hydroamination of ynamides with aromatic amines?
Organic & Biomolecular Chemistry Pub Date: 2021-02-24 DOI: 10.1039/D0OB02603D
Abstract
The Zn(OTf)2-catalyzed hydroamination of ynamides 2a–2l with aromatic amines 1a–1r was developed. This protocol features broad substrate scope of aromatic amines, good functional group tolerance for ynamides, and excellent regioselectivities. As a result, a variety of substituted amidine compounds 3aa–3oa, 3ab–3al and 3pa–3rk were prepared in moderate to excellent yields and with high regioselectivities.
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Journal Name：Organic & Biomolecular Chemistry
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CAS no.: 89640-58-4
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