Total synthesis of monosporascone and dihydromonosporascone?
Organic & Biomolecular Chemistry Pub Date: 2014-03-18 DOI: 10.1039/C4OB00331D
Abstract
The first total synthesis of monosporascone is presented. The five-step synthesis developed includes a silver acetylide-acid chloride coupling, domino Diels–Alder-retro-Diels–Alder reaction, and an intramolecular Friedel–Crafts acylation, and provides the natural product in 57% yield overall. Selective reduction of monosporascone also afforded the related metabolite dihydromonosporascone.
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Journal Name：Organic & Biomolecular Chemistry
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CAS no.: 89640-58-4
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