Total synthesis of (?)-nakadomarin A?

Chemical Communications Pub Date: 2011-08-08 DOI: 10.1039/C1CC13665H

Abstract

A highly diastereoselective bifunctional organocatalyst controlled Michael addition, a nitro-Mannich/lactamization cascade, a furanN-acyliminium cyclisation, a sequential alkyne RCM/syn-reduction and an alkene RCM has allowed a 19 step, highly stereoselective synthesis of (?)-nakadomarin A.

Graphical abstract: Total synthesis of (?)-nakadomarin A
Recommended Literature