Total chemical synthesis of lassomycin and lassomycin-amide?
Organic & Biomolecular Chemistry Pub Date: 2016-04-12 DOI: 10.1039/C6OB00631K
Abstract
Herein we report a practical synthetic route to the lasso peptide lassomycin (1) and C-terminal variant lassomycin-amide (2). The biological evaluation of peptides 1 and 2 against Mycobacterium tuberculosis revealed that neither had any activity against this bacterium. This lack of biological activity has led us to propose that naturally occurring lassomycin may actually exhibit a standard lasso peptide threaded conformation rather than the previously reported unthreaded structure.
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Journal Name：Organic & Biomolecular Chemistry
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CAS no.: 89640-58-4
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