Trifluoromethyl nitrogen heterocycles: synthetic aspects and potential biological targets

Chemical Communications Pub Date: 2016-01-14 DOI: 10.1039/C5CC09414C

Abstract

Recent advances regarding the synthetic chemistry of fluorinated aziridines, azetidines, pyrrolidines and their lactam/amino acid counterparts are presented. These heterocycles are of high importance both as building blocks for more complex structures and as active parts of medicinal chemistry-oriented compounds.

Graphical abstract: Trifluoromethyl nitrogen heterocycles: synthetic aspects and potential biological targets
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