γ-Carboline synthesis enabled by Rh(iii)-catalysed regioselective C–H annulation?
Chemical Communications Pub Date: 2020-10-05 DOI: 10.1039/D0CC04740F
Abstract
A redox-neutral Rh(III)-catalyzed C–H annulation of indolyl oximes was developed. Relying on the use of various alkynyl silanes as the terminal alkyne surrogates, the reaction exhibited a reverse regioselectivity, thus giving an exclusive and easy way for the synthesis of a wide range of substituent free γ-carbolines at C3 position with high efficiency. Deuterium-labelling experiments and kinetic analysis have preliminarily shed light on the working mode of this catalytic system.
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Journal Name：Chemical Communications
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CAS no.: 89640-58-4
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