UiO-type metal–organic frameworks with NHC or metal–NHC functionalities for N-methylation using CO2 as the carbon source?

Chemical Communications Pub Date: 2019-09-09 DOI: 10.1039/C9CC06659D

Abstract

We demonstrate the first metal–organic framework (MOF) that catalyzes N-methylation of amines using 1 atm CO2 and phenylsilane under ambient conditions. Compared with its homogeneous analog, the incorporation of N-heterocyclic carbene (NHC) into the MOF provides more efficient catalysis with improved reaction kinetics, turnover numbers and recyclability. Moreover, the metalated NHC functionalized MOF achieves direct N-methylation of amines bearing carboxylate moieties, which are common building blocks in pharmaceutical chemistry.

Graphical abstract: UiO-type metal–organic frameworks with NHC or metal–NHC functionalities for N-methylation using CO2 as the carbon source
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