The rapid synthesis of oxazolines and their heterogeneous oxidation to oxazoles under flow conditions?
Organic & Biomolecular Chemistry Pub Date: 2014-10-28 DOI: 10.1039/C4OB02105C
Abstract
A rapid flow synthesis of oxazolines and their oxidation to the corresponding oxazoles is reported. The oxazolines are prepared at room temperature in a stereospecific manner, with inversion of stereochemistry, from β-hydroxy amides using Deoxo-Fluor?. The corresponding oxazoles can then be obtained via a packed reactor containing commercial manganese dioxide.
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Journal Name:Organic & Biomolecular Chemistry
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CAS no.: 89640-58-4