The rapid synthesis of oxazolines and their heterogeneous oxidation to oxazoles under flow conditions?

Organic & Biomolecular Chemistry Pub Date: 2014-10-28 DOI: 10.1039/C4OB02105C

Abstract

A rapid flow synthesis of oxazolines and their oxidation to the corresponding oxazoles is reported. The oxazolines are prepared at room temperature in a stereospecific manner, with inversion of stereochemistry, from β-hydroxy amides using Deoxo-Fluor?. The corresponding oxazoles can then be obtained via a packed reactor containing commercial manganese dioxide.

Graphical abstract: The rapid synthesis of oxazolines and their heterogeneous oxidation to oxazoles under flow conditions
Recommended Literature