Triphenylphosphine-catalysed amide bond formation between carboxylic acids and amines?

Chemical Communications Pub Date: 2014-04-08 DOI: 10.1039/C4CC01861C

Abstract

Unactivated carboxylic acids and amines undergo organocatalytic Ph3P/CCl4-mediated amide bond formation by employing in situ reduction of triphenylphosphine oxide to triphenylphosphine in the presence of diethoxymethylsilane and bis(4-nitrophenyl)phosphate.

Graphical abstract: Triphenylphosphine-catalysed amide bond formation between carboxylic acids and amines
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