The synthesis of Bcr-Abl inhibiting anticancer pharmaceutical agents imatinib, nilotinib and dasatinib
Organic & Biomolecular Chemistry Pub Date: 2012-12-05 DOI: 10.1039/C2OB27003J
Abstract
Imatinib (1), nilotinib (2) and dasatinib (3) are Bcr-Abl tyrosine kinase inhibitors approved for the treatment of chronic myelogenous leukemia (CML). This review collates information from the journal and patent literature to provide a comprehensive reference source of the different synthetic methods used to prepare the aforementioned active pharmaceutical ingredients (API's).
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Journal Name：Organic & Biomolecular Chemistry
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CAS no.: 89640-58-4
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