The sustainable synthesis of peptidomimetics via chemoenzymatic tandem oxidation–Ugi reaction?
RSC Advances Pub Date: 2018-08-08 DOI: 10.1039/C8RA04583F
Abstract
A simply and green synthetic protocol based on the selective laccase-oxidation of alcohol to a corresponding aldehyde and a following Ugi reaction in a micellar system made of SDS was developed and is reported herein. Special emphasis was placed on the metal-free chemoenzymatic tandem reaction based on alcohol oxidation strategies using molecular oxygen from air, followed by an Ugi reaction. The reaction was carried out without the use of a transition metal or organic solvents as a reaction medium. The presented protocol offers an efficient and environmentally friendly procedure.
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Journal Name：RSC Advances
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CAS no.: 89640-58-4
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