The phosphatase-like activity of zirconium oxide nanoparticles and their application in near-infrared intracellular imaging?
Journal of Materials Chemistry B Pub Date: 2020-03-19 DOI: 10.1039/D0TB00450B
Abstract
In this study, the phosphatase mimetic activity of zirconium oxide nanoparticles (ZrO2 NPs) has been demonstrated. They can effectively catalyze the dephosphorylation of a series of commercial fluorogenic and chromogenic substrates of natural phosphatases. Compared with natural phosphatases, ZrO2 NPs possess several advantages such as low cost, facile preparation procedures, and high stability in a broader pH range or at high temperatures. In addition, the activity of ZrO2 NPs toward some important biomolecules was investigated. The ZrO2 NPs can catalyze the dephosphorylation of ATP and o-phospho-L-tyrosine, but they cannot react with DNA strands. These data are important for the further bio-related applications of ZrO2 NPs. Finally, the potential application of ZrO2 NPs in intracellular imaging is also demonstrated by using a near-infrared fluorescent substrate of alkaline phosphatase.
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Journal Name：Journal of Materials Chemistry B
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CAS no.: 89640-58-4
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