The furan route to tropolones: probing the antiproliferative effects of β-thujaplicin analogs?

Organic & Biomolecular Chemistry Pub Date: 2012-09-24 DOI: 10.1039/C2OB26553B

Abstract

A direct route to analogs of the naturally occurring tropolone β-thujaplicin has been developed in just four steps from furan. Using this method, a series of derivatives were synthesized and evaluated. Several of these compounds demonstrated very high levels of potency against bacterial and fungal pathogens with good selectivity over mammalian cells.

Graphical abstract: The furan route to tropolones: probing the antiproliferative effects of β-thujaplicin analogs
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