The decarboxylative C–H heteroarylation of azoles catalysed by nickel catalysts to access unsymmetrical biheteroaryls?

Organic Chemistry Frontiers Pub Date: 2019-11-05 DOI: 10.1039/C9QO01073D

Abstract

Nickel-catalysed direct decarboxylative C–H heteroarylation of azoles with heteroaryl carboxylic acids has been developed. This methodology provides a novel and efficient approach to construct various important unsymmetrical biheteroaryls with good functional group compatibility.

Graphical abstract: The decarboxylative C–H heteroarylation of azoles catalysed by nickel catalysts to access unsymmetrical biheteroaryls
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