Trihaloethenes as versatile building blocks for organic synthesis

Organic & Biomolecular Chemistry Pub Date: 2016-01-26 DOI: 10.1039/C6OB00091F

Abstract

This review highlights the chemistry of trihaloethene building blocks with a special focus on commercially available 1,1,2-trichloroethene. The topics surveyed herein include the use of trihaloethenes as C2-building blocks for transition metal-catalyzed coupling reactions, addition, elimination and cycloaddition reactions as well as natural product syntheses.

Graphical abstract: Trihaloethenes as versatile building blocks for organic synthesis
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