Trichloromethyl ketones: asymmetric transfer hydrogenation and subsequent Jocic-type reactions with amines?
Chemical Communications Pub Date: 2013-09-16 DOI: 10.1039/C3CC46070C
Abstract
Amino-amides are important pharmaceutical building-blocks. The enantioselective reduction of trichloromethyl ketones using ruthenium transfer hydrogenation catalysts is reported. The products react in a range of Jocic-type reactions to give enantiomerically enriched amino-amides.
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Journal Name：Chemical Communications
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CAS no.: 89640-58-4
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