Transcriptional regulatory proteins as biosensing tools?

Chemical Communications Pub Date: 2017-05-02 DOI: 10.1039/C6CC09512G

Abstract

We have developed sensing systems employing different classes of transcriptional regulatory proteins genetically and chemically modified to incorporate a fluorescent reporter molecule for detection of arsenic, hydroxylated polychlorinated biphenyls (OH-PCBs), and cyclic AMP (cAMP). These are the first examples of optical sensing systems based on transcriptional regulatory proteins.

Graphical abstract: Transcriptional regulatory proteins as biosensing tools
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