Trachycladindoles A–G: cytotoxic heterocycles from an Australian marine sponge, Trachycladus laevispirulifer?
Organic & Biomolecular Chemistry Pub Date: 2008-05-29 DOI: 10.1039/B803455A
Abstract
A southern Australian marine sponge, Trachycladus laevispirulifer, yielded the cytotoxic agents trachycladindoles A–G (1–7) as a selection of novel indole-2-carboxylic acids bearing a 2-amino-4,5-dihydroimidazole moiety. The trachycladindoles displayed promising selective cytotoxicity against a panel of human cancer cell lines and their structures were assigned on the basis of detailed spectroscopic analysis. Preliminary structure activity relationship (SAR) investigations by co-metabolite defined structural features key to the trachycladindole pharmacophore, highlighting an unusual bioactive molecular motif deserving of future investigation.
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Journal Name：Organic & Biomolecular Chemistry
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CAS no.: 89640-58-4
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