Synthesis of trifluoromethylthiolated pyridinones through the copper-mediated trifluoromethylthiolation of iodopyridinones?
Organic & Biomolecular Chemistry Pub Date: 2016-08-02 DOI: 10.1039/C6OB01348A
Abstract
An operationally simple method for the copper-mediated trifluoromethylthiolation of iodopyridinones employing (bpy)CuSCF3 (1; bpy = 2,2′-bipyridine) as a trifluoromethylthiolating reagent is presented. Various types of iodopyridinones are applicable and the trifluoromethylthiolated pyridinones are obtained in moderate to excellent yields. This method tolerates a variety of protecting groups on the nitrogen atom of pyridinones. In addition, scalability of the reaction is demonstrated.
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Journal Name：Organic & Biomolecular Chemistry
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CAS no.: 89640-58-4
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