Synthesis of the bis-spiroacetal C25–C40 moiety of the antimitotic agent spirastrellolide B using a bis-dithiane deprotection/spiroacetalisation sequence?

Chemical Communications Pub Date: 2010-05-05 DOI: 10.1039/C0CC00056F

Abstract

Use of a bis-dithiane deprotection–tandem bis-spiroacetalisation sequence was key to the successful synthesis of the [5,6,6]-bis-spiroacetal of the antimitotic agent spirastrellolide B, achieved in a highly convergent fashion involving successive dithiane alkylations.

Graphical abstract: Synthesis of the bis-spiroacetal C25–C40 moiety of the antimitotic agent spirastrellolide B using a bis-dithiane deprotection/spiroacetalisation sequence
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