Target-selective degradation of proteins by a light-activated 2-phenylquinoline-estradiol hybrid?

Chemical Communications Pub Date: 2007-08-10 DOI: 10.1039/B708947C

Abstract

A designed 2-phenylquinoline-estradiol hybrid effectively and selectively degraded the target transcription factor, human estrogen receptor-α (hER-α), which has a high affinity with the estradiol moiety, under long-wavelength UV photo-irradiation, without additives and under neutral conditions.

Graphical abstract: Target-selective degradation of proteins by a light-activated 2-phenylquinoline-estradiol hybrid
Recommended Literature