Synthesis of cyano-substituted carbazoles via successive C–C/C–H cleavage?
Organic & Biomolecular Chemistry Pub Date: 2019-01-04 DOI: 10.1039/C8OB03031F
Abstract
A highly efficient protocol for the synthesis of polysubstituted cyano carbazoles has been developed. This process is realized through the tandem reactions of Cs2CO3 promoted C–C σ-bond activation of α-cyano ketones followed by Fe-catalyzed selective C–H and/or C–C bond activations. Two of the sp2 C–H bonds are functionalized, and two of the C–C σ-bonds are cleaved involving a 1,2-acyl migration during the reaction process.
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Journal Name：Organic & Biomolecular Chemistry
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CAS no.: 89640-58-4
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