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Synthesis of novel chromene scaffolds for adenosine receptors?

Organic & Biomolecular Chemistry Pub Date: 2011-04-20 DOI: 10.1039/C1OB05305A

Abstract

A one-pot procedure was developed for the synthesis of novel 3-[amino(methoxy)methylene]-2-oxo-3,4-dihydro-2H-chromen-4-yl)-3-cyanoacetamides and chromeno[3,4-c]pyridine-1-carbonitriles from the reaction of 2-oxo-2H-chromene-3-carbonitriles and cyanoacetamides. These chromene derivatives were identified as new scaffolds for adenosine receptors and the hits 3a, 3c, 5a, and 5b were found.

Graphical abstract: Synthesis of novel chromene scaffolds for adenosine receptors

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Organic & Biomolecular Chemistry

Journal Name：Organic & Biomolecular Chemistry

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