Concise synthesis of N-thiomethyl benzoimidazoles through base-promoted sequential multicomponent assembly?
RSC Advances Pub Date: 2019-09-26 DOI: 10.1039/C9RA06144D
Abstract
An efficient method for the synthesis of N-thiomethyl benzimidazoles from o-phenylenediamines, thiophenols, and aldehydes via C–N/C–S bond formation under metal-free conditions is described. A broad range of functional groups attached to the substrates were well tolerated in this reaction system. Stable and low-toxicity paraformaldehyde was used as the carbon source.
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Journal Name：RSC Advances
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CAS no.: 89640-58-4
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