Synthesis of macromolecular systems via lipase catalyzed biocatalytic reactions: applications and future perspectives?

Chemical Society Reviews Pub Date: 2016-10-27 DOI: 10.1039/C6CS00147E

Abstract

Enzymes, being remarkable catalysts, are capable of accepting a wide range of complex molecules as substrates and catalyze a variety of reactions with a high degree of chemo-, stereo- and regioselectivity in most of the reactions. Biocatalysis can be used in both simple and complex chemical transformations without the need for tedious protection and deprotection chemistry that is very common in traditional organic synthesis. This current review highlights the applicability of one class of biocatalysts viz. “l(fā)ipases” in synthetic transformations, the resolution of pharmaceutically important small molecules including polyphenols, amides, nucleosides and their precursors, the development of macromolecular systems (and their applications as drug/gene carriers), flame retardants, polymeric antioxidants and nanocrystalline solar cells, etc.

Graphical abstract: Synthesis of macromolecular systems via lipase catalyzed biocatalytic reactions: applications and future perspectives
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