Synthesis of ketones via organolithium addition to acid chlorides using continuous flow chemistry?
RSC Advances Pub Date: 2015-09-14 DOI: 10.1039/C5RA14890A
Abstract
An efficient method for the synthesis of ketones using organolithium and acid chlorides under continuous flow conditions has been developed. In contrast to standard batch chemistry, over-addition of the organolithium to the ketone for the formation of the undesired tertiary alcohol has been minimised representing a direct approach toward ketones.
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Journal Name：RSC Advances
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CAS no.: 89640-58-4
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