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The in vitrotransport of model thiodipeptide prodrugs designed to target the intestinal oligopeptide transporter, PepT1?

Organic & Biomolecular Chemistry Pub Date: 2009-07-20 DOI: 10.1039/B909221H

Abstract

A thiodipeptide carrier system is shown to be effective at enabling a range of covalently bound molecules, including benzyl, benzoyl and ibuprofen conjugates, to be transported via the intestinal peptide transporter PepT1, demonstrating its potential as a rational drug delivery target.

Graphical abstract: The in vitrotransport of model thiodipeptide prodrugs designed to target the intestinal oligopeptide transporter, PepT1

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Organic & Biomolecular Chemistry

Journal Name：Organic & Biomolecular Chemistry

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