Synthesis of chiral piperazin-2-ones through palladium-catalyzed asymmetric hydrogenation of pyrazin-2-ols?
Organic Chemistry Frontiers Pub Date: 2021-09-14 DOI: 10.1039/D1QO01144H
Abstract
A palladium-catalyzed asymmetric hydrogenation of pyrazines containing a tautomeric hydroxyl group has been developed, providing a facile access to chiral disubstituted piperazin-2-ones with excellent diastereoselectivities and enantioselectivities. The product could be conveniently converted into chiral piperazines without loss of optical purity.
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Journal Name：Organic Chemistry Frontiers
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CAS no.: 89640-58-4
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