Symmetry assisted tuning of bending and brittle multi-component forms of probenecid?

Chemical Communications Pub Date: 2017-03-03 DOI: 10.1039/C7CC01091E

Abstract

The mechanical flexibility known in the antihyperuricemia drug probenecid has been extended into multi-component systems using co-formers with two donor or acceptor sites, in contrast to systems with a single H-bond acceptor that exhibit brittle behaviour. The piperazinium salt demonstrates that GRAS co-formers can be used to maintain mechanical flexibility with drug molecules.

Graphical abstract: Symmetry assisted tuning of bending and brittle multi-component forms of probenecid
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