Synthesis of thioamides via one-pot A3-coupling of alkynyl bromides, amines, and sodium sulfide?
Organic & Biomolecular Chemistry Pub Date: 2013-11-19 DOI: 10.1039/C3OB42275E
Abstract
We herein describe a novel method for the synthesis of thioamides by a three component condensation of alkynyl bromides, amines, and Na2S·9H2O. The developed method is applicable for a wide range of amines and alkynyl bromides bearing different functional groups furnishing the corresponding products in moderate to excellent yields.
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Journal Name：Organic & Biomolecular Chemistry
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CAS no.: 89640-58-4
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