Switching glycosyltransferase UGTBL1 regioselectivity toward polydatin synthesis using a semi-rational design?
Organic & Biomolecular Chemistry Pub Date: 2018-03-15 DOI: 10.1039/C8OB00376A
Abstract
The 62nd residue of glycosyltransferase UGTBL1 was identified as a “hotspot” for glycosylation at 3-OH of resveratrol. Via semi-rational design including structure-guided alanine scanning and saturation mutations, the mutation I62G significantly switched the regioselectivity from 4′-OH to 3-OH of resveratrol and mainly produced polydatin (87.7%), a therapeutic natural product.
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Journal Name：Organic & Biomolecular Chemistry
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CAS no.: 89640-58-4
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