Synthesis of tetronic acids from propargylic alcohols and CO2?
Chemical Communications Pub Date: 2018-05-09 DOI: 10.1039/C8CC03039A
Abstract
A direct and practical synthesis of important tetronic acids from easily available propargylic alcohols and carbon dioxide is reported for the first time. This transition-metal-free transformation features high atom- and step-economy, mild reaction conditions, good functional group tolerance and high yield. Preliminary mechanistic studies suggest that the reaction proceeds via cyclization to give alkylidene cyclic carbonate, ring-opening and re-cyclization processes.
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Journal Name：Chemical Communications
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CAS no.: 89640-58-4
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