Synthesis of quinolines via copper-catalyzed domino reactions of enaminones?
Organic & Biomolecular Chemistry Pub Date: 2017-08-18 DOI: 10.1039/C7OB01867C
Abstract
Quinoline derivatives were obtained from enaminones and 2-bromo- or 2-iodobenzaldehydes via copper-catalyzed domino reactions consisting of the aldol reaction, C(aryl)–N bond formation and elimination. The electronic effect of aldehydes played a major role in the reaction outcome. Two simple protocols are disclosed to achieve various quinolines from both cyclic and acyclic enaminones in good yields. With the less-reactive acyclic enaminones, diethyl-2-(2-bromobenzylidene)malonate was shown to be more compatible than the benzaldehydes.
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Journal Name：Organic & Biomolecular Chemistry
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CAS no.: 89640-58-4
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