α-Arylation of (hetero)aryl ketones in aqueous surfactant media?
Green Chemistry Pub Date: 2021-06-22 DOI: 10.1039/D1GC01572A
Abstract
α-Arylation reactions can be performed in water, enabled by a designer surfactant,under mild conditions and in the absence of organic co-solvents. A multitude of aryl and heteroaryl ketones are amenable to coupling with functionalized aryl halides. Use of a lipophilic base that can gain entry to the micellar inner cores mediates enolization. In some cases, palladium loadings as low as 2500 ppm (0.25 mol%) are sufficient for coupling in a completely recyclable medium, exemplifying chemistry in water.
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Journal Name：Green Chemistry
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CAS no.: 89640-58-4
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