ZrCl2(η-C5Me5)2-AlHCl2·(THF)2: efficient hydroalumination of terminal alkynes and cross-coupling of the derived alanes?

Chemical Communications Pub Date: 2013-01-14 DOI: 10.1039/C2CC37537K

Abstract

Stabilized AlHCl2·(THF)2 hydroaluminates RC[triple bond, length as m-dash]CH with exceptional chemo-, regio- and stereoselectivity under efficient ZrCl2(η-C5Me5)2 catalysis (2–5 mol%). The resulting vinyl alanes undergo palladium cross-coupling with a wide range of sp2 electrophiles (aryl, heteroaryl and vinyl halides/pseudohalides) in good to excellent yields.

Graphical abstract: ZrCl2(η-C5Me5)2-AlHCl2·(THF)2: efficient hydroalumination of terminal alkynes and cross-coupling of the derived alanes
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