The development of a short route to the API ropinirole hydrochloride?
Organic & Biomolecular Chemistry Pub Date: 2015-08-28 DOI: 10.1039/C5OB01739D
Abstract
A four-step, three-stage synthesis of the API ropinirole hydrochloride has been developed from a commercially available naphthalene derivative. The new route has half the step-count and twice the overall yield of the current manufacturing process. Key features of the synthesis are a regioselective Birch reduction and an ozonolysis with concomitant ring closure to induce the required ring contraction.
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Journal Name：Organic & Biomolecular Chemistry
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CAS no.: 89640-58-4
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