Synthesis of N-arylsulfonamides via Fe-promoted reaction of sulfonyl halides with nitroarenes in an aqueous medium?
Organic & Biomolecular Chemistry Pub Date: 2018-06-27 DOI: 10.1039/C8OB01172A
Abstract
A fascinating Fe-promoted protocol for the synthesis of N-arylsulfonamides has been developed. Starting from commercially available nitroarenes and sulfonyl chlorides, moderate to excellent yields of the corresponding N-arylsulfonamides can be obtained. In particular, Fe dust serves as the sole reductant in the transformation and it can be easily performed on a large scale.
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Journal Name:Organic & Biomolecular Chemistry
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CAS no.: 89640-58-4