The C29–C34 parts of antitumor macrolide aplyronine A serve as versatile actin-affinity tags?
Chemical Communications Pub Date: 2021-09-17 DOI: 10.1039/D1CC04259A
Abstract
Anticancer drug development inspired by natural products based on protein–protein interactions (PPI) is a promising strategy. We developed structurally-simplified C29–C34 side-chain analogs of aplyronine A (ApA), an antitumor marine macrolide. Among them, the analog possessing the C23 acyloxy group, the C29 N,N-dimethyl-L-alanine ester and the C34 N-methyl enamide showed potent actin-depolymerizing activity. Binding kinetics, molecular docking, and affinity-purification experiments revealed that they are versatile actin-affinity tags to accelerate studies on the mode of action related to cytoskeletal dynamics and the development of PPI-based drug leads.
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Journal Name：Chemical Communications
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CAS no.: 89640-58-4
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